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A-175 Block 13-C KDA Scheme 24

Gulshan-e-Iqbal 75300 Karachi, Pakistan

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Cross linked Verus non-cross linked

Cross-linked Hyaluronic Acid

Complex HA- Resistant to Break down by 3 enzymes

Longer Half-life 3-6 months (Depending upon cross linking technique

High Penetration in the in Cartilage

Enhanced Endogènes HA Production

Provides high Visco-Elasticity

High G modulus of elasticity & Viscosity

Single dose injection treatment regimen per year

Documented to provide better clinical outcome

Non-Cross-linked Hyaluronic Acid

Linear Chain Hyaluronic acid easy to break down

12-72 hours half-life (Hyaluronidase, glucuronidase & hexosaminidase enzyme breakdown NCHA

Low penetration in the cartilage

Does not enhance Endogenous HA production

Low Visco-Elastic properties

Low G modulus of elasticity & Viscosity

Low visco-elastic properties

No significant improvement in clinical outcomes

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